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Milan Mrksich

from Hinsdale, IL
Age ~51

Milan Mrksich Phones & Addresses

  • 552 N Vine St, Hinsdale, IL 60521 (630) 789-3185
  • 552 Vine St, Hinsdale, IL 60521 (630) 789-3185
  • 155 Harbor Ave, Chicago, IL 60601 (312) 240-0225
  • 414 W Wisconsin St #D, Chicago, IL 60614 (773) 337-3997
  • 414 Wisconsin St, Chicago, IL 60614 (773) 337-3997 (312) 337-3997
  • Pasadena, CA
  • Cambridge, MA
  • 552 N Vine St, Hinsdale, IL 60521 (773) 337-3997

Work

Company: University of chicago Position: Professor

Education

School / High School: University of Illinois at Urbana-Champaign 1986 to 1989

Industries

Biotechnology

Resumes

Resumes

Milan Mrksich Photo 1

Professor At University Of Chicago

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Position:
Professor at University of Chicago
Location:
Greater Chicago Area
Industry:
Biotechnology
Work:
University of Chicago
Professor
Education:
University of Illinois at Urbana-Champaign 1986 - 1989

Publications

Us Patents

Method Of Forming Articles Including Waveguides Via Capillary Micromolding And Microtransfer Molding

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US Patent:
6355198, Mar 12, 2002
Filed:
Jan 8, 1998
Appl. No.:
09/004583
Inventors:
Enoch Kim - Boston MA
Younan Xia - Seattle WA
Milan Mrksich - Chicago IL
Rebecca J. Jackman - Boston MA
Xiao-Mei Zhao - Shaker Heights OH
Stephen P. Smith - Newton MA
Mara G. Prentiss - Cambridge MA
George M. Whitesides - Newtown MA
Christian Marzolin - Paris,
Assignee:
President and Fellows of Harvard College - Cambridge MA
International Classification:
B29C 3910
US Classification:
264259, 264299, 264330
Abstract:
Chemically or biochemically active agents or other species are patterned on a substrate surface by providing a micromold having a contoured surface and forming, on a substrate surface, a chemically or biochemically active agent or fluid precursor of a structure. A chemically or biochemically active agent or fluid precursor also can be transferred from indentations in an applicator to a substrate surface. The substrate surface can be planar or nonplanar. Fluid precursors of polymeric structures, inorganic ceramics and salts, and the like can be used to form patterned polymeric articles, inorganic salts and ceramics, reactive ion etch masks, etc. at the surface. The articles can be formed in a pattern including a portion having a lateral dimension of less than about 1 millimeter or smaller. The indentation pattern of the applicator can be used to transfer separate, distinct chemically or biochemically active agents or fluid precursors to separate, isolated regions of a substrate surface. Waveguide arrays, combinatorial chemical or biochemical libraris, etc.

Surface Modifying Composition

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US Patent:
2005025, Nov 17, 2005
Filed:
May 6, 2005
Appl. No.:
11/124022
Inventors:
Milan Mrksich - Chicago IL,
Yan-Yeung Luk - Manlius NY,
International Classification:
H01L021/00
C12M001/34
C07C323/39
US Classification:
435287200, 438001000, 560148000, 564049000
Abstract:
Alkanethiols of formula (1) and the enantimomers of the alkanethiol of formula (1): HS-L-Q-T  (1), and disulfides of formula (3) and the enantimomers of the disulfide of formula (3): T-Q-L-S—S-J  (3), where -T is a moiety of formula (2) Rand Rare each individually selected from the group consisting of H and OH; a is 0 to 3; b is 0 to 3; and indicates that the chirality of the carbon atom to which it is attached is either R or S; may form inert surfaces that prevent the unwanted adsorption of proteins and cells.

Methods Of Etching Articles Via Microcontact Printing

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US Patent:
5900160, May 4, 1999
Filed:
Jul 9, 1996
Appl. No.:
8/677309
Inventors:
George M. Whitesides - Newton MA
Younan Xia - Cambridge MA
James L. Wilbur - Germantown MD
Rebecca J. Jackman - boston MA
Enoch Kim - boston MA
Mara G. Prentiss - Cambridge MA
Milan Mrksich - Chicago IL
Amit Kumar - Milpitas CA
Christopher B. Gorman - Raleigh NC
Hans Biebuyck - Thalwil,
Karl K. Berggren - Cambridge MA
Assignee:
President and fellows of Harvard College - Cambridge MA
International Classification:
B44C 122
US Classification:
216 41
Abstract:
Improved methods of forming a patterned self-assembled monolayer on a surface and derivative articles are provided. According to one method, an elastomeric stamp is deformed during and/or prior to using the stamp to print a self-assembled molecular monolayer on a surface. According to another method, during monolayer printing the surface is contacted with a liquid that is immiscible with the molecular monolayer-forming species to effect controlled reactive spreading of the monolayer on the surface. Methods of printing self-assembled molecular monolayers on nonplanar surfaces and derivative articles are provided, as are methods of etching surfaces patterned with self-assembled monolayers, including methods of etching silicon. Optical elements including flexible diffraction gratings, mirrors, and lenses are provided, as are methods for forming optical devices and other articles using lithographic molding. A method for controlling the shape of a liquid on the surface of an article is provided, involving applying the liquid to a self-assembled monolayer on the surface, and controlling the electrical potential of the surface.

Platelet Aggregation Inhibitors

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US Patent:
2012025, Oct 4, 2012
Filed:
Sep 2, 2010
Appl. No.:
13/393608
Inventors:
Milan Mrksich - Hinsdale IL,
Juan Sanchez-Cortes - Chicago IL,
Assignee:
UNIVERSITY OF CHICAGO - Chicago IL
International Classification:
C07K 7/64
A61P 7/02
C07K 5/08
A61K 38/12
A61K 38/08
C07K 7/06
A61P 7/04
A61P 9/00
US Classification:
514 137, 514 138, 514 164, 514 211, 514 217, 530317, 530329
Abstract:
Peptides and cyclized analogs thereof that are useful as platelet aggregation inhibitors in the treatment of cardiac disease, including acute coronary syndrome are disclosed.

Polypeptide Immobilization

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US Patent:
2012014, Jun 7, 2012
Filed:
Feb 4, 2011
Appl. No.:
12/984948
Inventors:
Milan Mrksich - Chicago IL,
Christian Hodneland - Brookline MA,
International Classification:
C40B 30/04
G01N 33/573
G01N 33/53
US Classification:
506 9, 436501, 435 71
Abstract:
The present invention provides a method, comprising (a) providing a reactant ligand attached to a substrate; (b) contacting the substrate with a fusion polypeptide, said fusion polypeptide comprising a capture polypeptide fused to a display polypeptide under conditions such that said reactant ligand covalently binds to said capture polypeptide; and (c) analyzing said display polypeptide.

Immunoassays And Characterization Of Biomolecular Interactions Using Self-Assembled Monolayers

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US Patent:
2010011, May 6, 2010
Filed:
Sep 23, 2009
Appl. No.:
12/565575
Inventors:
Milan Mrksich - Hinsdale IL,
Violeta L. Marin - Chicago IL,
Steven M. Patrie - Dallas TX,
International Classification:
G01N 33/53
US Classification:
436501
Abstract:
The present disclosure relates to methods of characterizing protein-protein interaction or conducting immunoassays in a biological sample using self-assembled monolayers (SAMs) and matrix-assisted laser desorption/ionization time of flight mass spectrometry (SAMDI). The biological sample may be obtained from a living subject, such as a human or animal clinical sample containing multiple unknown proteins and/or antigens. Label-free methods of identifying protein-protein interactions, antigen-antibody binding and/or diagnosing a medical condition based on analysis of a biological sample using SAMDI are also provided, as well as biochips comprising surface bound proteins and/or antibodies and methods of making these biochips. The methods and biochips are useful, for example, for identifying protein-protein binding interactions and/or conducting immunoassays in samples such as humoral fluids or other clinical samples, cell lysates, tissue lysates, tumor lysates, and samples obtained, isolated or derived from animals or plants.

Characterization Of Biochips Containing Self-Assembled Monolayers

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US Patent:
2010000, Jan 7, 2010
Filed:
Jan 4, 2005
Appl. No.:
11/029224
Inventors:
Milan Mrksich - Chicago IL,
Jing Su - Chicago IL,
International Classification:
C40B 30/10
C12Q 1/00
C12Q 1/48
C12Q 1/37
G01N 33/543
US Classification:
506 12, 435 4, 435 15, 435 23, 436518
Abstract:
The present invention relates to a method of characterizing biochips with matrix-assisted laser desorption/ionization and time of flight mass spectrometry (MALDI-TOF MS).

Molded Waveguides

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US Patent:
2008011, May 22, 2008
Filed:
Dec 12, 2007
Appl. No.:
12/001564
Inventors:
Enoch Kim - Boston MA,
Younan Xia - Seattle WA,
Milan Mrksich - Chicago IL,
Rebecca Jackman - Boston MA,
Xiao-Mei Zhao - Pepper Pike OH,
Stephen Smith - Medford MA,
Mara Prentiss - Belmont MA,
George Whitesides - Newton MA,
Christian Marzolin - Paris,
Assignee:
President and Fellows of Harvard College - Cambridge MA
International Classification:
B29C 45/16
US Classification:
264259000
Abstract:
Chemically or biochemically active agents or other species are patterned on a substrate surface by providing a micromold having a contoured surface and forming, on a substrate surface, a chemically or biochemically active agent or fluid precursor of a structure. A chemically or biochemically active agent or fluid precursor also can be transferred from indentations in an applicator to a substrate surface. The substrate surface can be planar or non-planar. Fluid precursors of polymeric structures, inorganic ceramics and salts, and the like can be used to form patterned polymeric articles, inorganic salts and ceramics, reactive ion etch masks, etc. at the surface. The articles can be formed in a pattern including a portion having a lateral dimension of less than about 1 millimeter or smaller. The indentation pattern of the applicator can be used to transfer separate, distinct chemically or biochemically active agents or fluid precursors to separate, isolated regions of a substrate surface. Waveguide arrays, combinatorial chemical or biochemical libraris, etc. can be made. Differences in refractive index of waveguide and cladding can be created by subjecting the waveguide and cladding, made of identical prepolymeric material, to different polymerization or cross-linking conditions. Interferometers are defined by coupling arrays of waveguides, where coupling can be controlled by altering the difference in refractive index between cladding and waveguide at any desired location of the array. Alteration and refractive index can be created photochemically, chemically, or the like. Sensors also are disclosed, including biochemical sensors.
Milan Mrksich from Hinsdale, IL, age ~51 Get Report